Welcome to the Miao Lab

We are a highly interdisciplinary research lab in the Department of Molecular Biosciences and Center for Computational Biology at the University of Kansas. Our research is focused on the development of novel theoretical and computational methods, which accelerate modern computer simulations by orders of magnitude, and the application of these methods in advanced biomolecular and cellular modeling and computer-aided drug design. In collaboration with leading experimental groups, we combine complementary simulations and experiments on in-depth studies and drug discovery of functionally important biomolecules and cellular signaling pathways.

At the interface of computational biology, chemistry, biophysics, bioinformatics and pharmacology, our research aims to address three major topics: (i) Computer-aided drug design of G-protein-coupled receptors (GPCRs) and other important targets, (ii) method development for enhanced simulations of biomolecular diffusion and recognition in crowded cellular environments, and (iii) multiscale modeling of cellular signaling pathways that are relevant to neurological disorders, heart failure and cancer.

Postdoc Position Available:

We are currently looking for a highly motivated Postdoctoral Researcher to work on biomolecular modeling and computer-aided drug discovery. Projects in the lab involve computer-aided drug discovery, method development for enhanced simulations of biomolecular recognition, and multiscale modeling of cellular signaling processes. In collaboration with leading experimentalists, the new postdoc will have the opportunity to work on unprecedented simulations and drug design of membrane proteins, which are extremely important targets for treating Alzheimers disease and human cancers. Please click here for the job description and application instructions.

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